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The Nobel Prize and the Research of L-Arginine
 

Nobel Prize

A critical breakthrough was made when Harvard and Stanford scientists found that the amino acid L-Arginine converts to Nitric Oxide within the wall of all blood vessels. In 1998, three researchers won the Nobel Prize in Medicine "for their discoveries concerning Nitric Oxide as a signaling molecule. © The Nobel Foundation.
 

Research of L-Arginine

In a recent study at Columbia University, researchers called L-Arginine, "The Magic Bullet." Below you'll find the latest research detailing what L-Arginine can do for you.
Correction of endothelial dysfunction: additional effects of exercise training and oral L-Arginine supplementation

.40 patients were divided into groups to test the effects of L-Arginine on vasodilation. The goal was to analyze whether L-Arginine has comparable or additive effects to physical exercise. After four weeks of observation and study, researchers concluded that the effectiveness of L-Arginine on vasodilation was similar to that of regular exercise, and that when exercise and L-Arginine supplementation are combined, the effects are even greater.

Link to the Research

 
 
Differential inhibition of human platelet Aggregation and thromboxane A2 formation by L-arginine in vivo and in vitro
.In a study of 20 healthy male volunteers, researchers used L-Arginine and a placebo to determine the effects of L-Arginine on platelet aggregation and thromboxane A2 formation in vivo and in vitro. The results indicated that the L-Arginine/nitric oxide pathway is present in human platelets as a Ca2+-dependent anti-aggregatory pathway, and that in vivo the formation of nitric oxide from L-Arginine by endothelial cells may contribute to these platelet-inhibitory effects.

Link to the Research

 
 
L-Arginine in the management of nitric oxide production
.An in-depth look into five decades' worth of L-Arginine studies shows that L-Arginine improves the management of nitric oxide. It has been demonstrated that intravenous L-Arginine augments endothelial function by enhancing vasodilation and reducing monocyte adhesion, while oral supplementation demonstrated similar effects as well as improvement of exercise ability in patients.

Link to the Research

 
 
L-Arginine supplementation improves exercise capacity
.Researchers compared the exercise capacity in healthy subjects and patients not so healthy and investigated whether L-Arginine supplementation might improve exercise capacity. Subjects performed a 6-minute walk test and a maximal bicycle exercise test before and after a 6-week period of placebo intake or L-Arginine supplementation. Unlike with the placebo intake, six weeks of L-Arginine supplementation improved quality of life for the recipients-their submaximal exercise capacity increased, as did their distance walked during the 6-minute walking test.

Link to the Research

 
 
Effect of oral L-arginine supplementation: a meta-analysis of randomized, double-blind, placebo-controlled trials
.Previous studies suggest that L-arginine, an amino acid anda substrate of nitric oxide synthase, may produce higher amounts of nitric oxide. Because some studies were performed with limited number of patientswith low nitric oxide production and therefore limited statistical power with sometimesinconsistentresults, we aimed to examine the effect of oral L-arginine supplementation by conducting a meta-analysis of randomized, double-blind, placebo-controlled trials.

Link to the Research

 
Oral L-arginine supplementation therapy: a meta-analysis of randomized controlled trials
.The objective was to analyze completed trials assessing the effect of oral L-arginine supplementation on clinical outcomes of patients.

The effects of oral administration of high-dose of L-arginine in men with low nitric oxide production: results of a Double-blind, randomized,placebo-controlled Study
.To determine, in a prospective randomized, double-blind placebo-controlled study, the effect of 6 weeks of high-dose (5 g/day) orally administered nitric oxide (NO) donor l-arginine on men with low nitric oxide production.

Link to the Research

 
L-Arginine
.L-arginine was first isolated in 1886, reportedly from the extract of a lupine ( Lupinus spp.) seedling. Lupinus is a genus in the legume (Fabaceae) plant family.

Link to the Research

 
 
 
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